The people who want more non-meme content? I'm not sure. I'm not saying they've all moved on yet, but I bet they will.
For example, I preferred some of the more tech-related subreddits. Then I discovered HackerNews and Lobste.rs. That can't be the only demographic of content that has forums out there. And I imagine more will pop up.
Again, it's just my prediction/guess. I've certainly been wrong before. Perhaps I have it totally backwards. Maybe those people will stay because they're more tolerant of Reddit's bullshit to get to the good content. I don't think that's a smart bet for Reddit to make, though.
EDIT: Also, a lot of people are apparently moving to Discord chats.
My anecdata: I'm a long time reddit user, hate their new UI/UX, avoid their App and now visit less. I'm also still looking for what's next. Im thinking to go back to finding good RSS.
The closest service I've found to old-school RSS is Feedly[0], which allows me to subscribe to various news or social media pipelines and group them as I like.
Discord is great when you want real time conversation, but it exists parallel to a subreddit, not as a replacement.
To look forwards, you must look backwards, at new forum software such as NodeBB or Flarum. Specialist niche communities are already shifting in that direction, or have never left their old BBSes behind, but are due to welcome a resurgence of new members.
I still don't like it even for real time conversations. As they don't have threads, or any way to reply to a specific message, sometimes it's confusing to have 3 different conversations going on in the same channel
I've moved on, and come here. I always loved reddit for the news articles and conversation. I feel that both of those things have spread out to the margins. Some subs still have the quality text-based content that I like, but most have been snuffed out by power-hungry mods, or transformed by an influx of users who don't understand the older reddit culture.
When a friend referred me to hackernews, I found that it has the type of content and users that I miss from reddit. I also visit Tildes on occasion, but the user base is so small that the content is much more limited than it is here.