I've been running hass for quite some time, for years directly in a python venv on a Pi2, then Pi3, and now happily on a Pi4 4GB for several years. Runs so well I decided not to upgrade to a 5. Use both zigbee and zwave.

Currently running in docker, which was a godsend when I migrated from Raspbian to NixOS about 18 months or so ago with no issues.

Have used an SSD wherever possible, perhaps that's why it's been so stable.

I use the GPIO, which is one reason I've stuck with the Pi!