> IMO, everybody should take at least 2g daily in a couple of doses
I strongly caution against this kind of blanket recommendation. For most people, taking such a high dose without medical guidance is unwise. Unless a healthcare professional has specifically advised it, this level of supplementation goes well beyond established guidelines.
There is substantial research highlighting potential risks, including kidney damage, associated with high-dose vitamin C intake (as referenced elsewhere in this thread).
Anyone considering this should thoroughly research the risks and consult a qualified medical professional before proceeding.
Taking vitamin C orally decreases muscle mitochondrial biogenesis and harms the health benefits of training, like increased insulin resistance. (well established from multiple studies, easy to google).
There was huge antioxidant craze in late 90's and 00's when taking antioxidant supplements like C was considered the right thing to do. Now we know that just taking more antioxidants does not directly help with oxidization tress, because it messes up metabolism and can even increase it.
> well established from multiple studies, easy to google
That's not all of them. You can find systematic reviews and meta-analyses walking trough them all. Easy to google.
50-100 mg per day is OK and possible has some benefits, if you go to more than 2 grams like you suggested for health person, there is no evidence of benefits, only harms.
Phrases like "get serious" don’t contribute meaningfully to the discussion. This is a serious topic and deserves a well-informed, balanced perspective.
Recommending that people take over 2 grams of vitamin C daily -- without context or medical guidance —- is irresponsible. I'm sorry, but offering such advice in a public forum without acknowledging potential risks or the need for individual consideration can be genuinely harmful.
There are a large number of studies on this topic, in part because vitamin C supplements are so widely used and easily accessible. Several people have already shared relevant research in this thread.
Before promoting high-dose supplementation as universally safe or beneficial, I strongly recommend doing more in-depth research. It’s important to understand the potential risks especially since this kind of advice, if followed without medical oversight, can have serious health consequences.
If you are asserting that Linus Pauling was the only two-time winner of the Nobel Prize, my doubt in the accuracy of your conclusions has only increased, given that Marie Curie, John Bardeen, and Frederick Sanger have all won two Nobel Prizes.
Pauling took 18g every day, for decades. It's in his book. There is little doubt Pauling would do the same today. He would reject LPI though (as apart from his name, they don't follow his footsteps), but not orthomolecular.
Please don't spread fear here, vitamin C is non-toxic and can only help people, and this place represents a hacking oriented culture.
Find me a case report about the danger of vitamin C (not a theoretical one) and we can talk. Otherwise, you are free to behave and believe in whatever you want.
Are you serious? Prolonged high supplementation doses is actually very dangerous. Aside from the warnings about this in various places, I’ve also had a family member who did permanent kidney damage by prolonged usage of supplementation.
It shows no deaths from vitamins. This is from 2018, but its like that every year. While it doesn't account for damage as its highly uncertain to pinpoint exactly what happened in any human, at least you know there are no deaths, while at the same time, there are deaths for any drug (aspirin for example).
> I’ve also had a family member who did permanent kidney damage by prolonged usage of supplementation.
You mean, you or your doctors suppose it was about supplementation? And what supplementation? You can damage yourself or die with anything, water included, or you come with defective organ from the day 0. All that is not relevant for others.
Bashing on supplements is in any case irresponsible and you spread fear because you are not informed, its similar to anti-vacc movement - it never happens that entire technology domain is invalid - particular instance of drug/supplement/vaccine/herb can be.
The risk to kidneys is well documented. You seem to be concentrating on whether a person dies or not, but the risk to quality of life is not to be dismissed either. There are innumerable warnings and studies about this over the years.
IMO, everybody should take at least 2g daily in a couple of doses, particularly smokers.