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>I had my genome done last year, and I have completely buggered serotonin and dopamine systems, and an overamped oxycontin system.

May I ask where did you get it done? Is this something I can gather from my 23&me results?



Yes. Download your full data set from them and run it through promethease. Last I checked you can use the desktop version, choose the paid version, and their amazon checkout implementation is broken so you get the new interface, faster processing, and you don't have to submit your genotype with identifying info that way.

Edit: specifically, I have two short form 5-HTTLPR (gs290) (serotonin transport) (and various other uncommon serotonin linked SNPs, some linked with suicidal behaviour and schizophrenia, woohoo), rs1800497(C;T), which would be the origin of my absent dopamine reward cycle, rs6323(G;G), which interferes with serotonin, dopamine, epineprine, and norepinephrine.

Oh, and I have a grab-bag of SNPs both common and uncommon, which taken together mean that the vast majority of antidepressants and many painkillers (opiates) simply do not work on me - no pain relief, just extra pain and nausea... fun times in hospital when I learned that one.


After reading up on this addictive topic, it makes a lot of sense that you have a very high IQ. I bet you also have rs4680(G;G):

http://en.wikipedia.org/wiki/Catechol-O-methyl_transferase


Close but no cigar - I'm A;G - worst of both worlds!




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